Effect of Zinc on Acute Pulmonary Edema and Changes of Essential Metal Contents Ptoduced by Nitrogen Dioxide Exposure to Mice
1992 Volume 27 Issue 1 Pages 58-64
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1992 Volume 27 Issue 1 Pages 58-64
The lung weight of CD-1 female mice exposed to NO2 increased with the augmentation of NO2 concentration, and the increase was reduced by Zn pretreatment. The Ca content in lung after NO2 exposure had increased and the rise was depressed by Zn pretreatment The Zn content in lungs of saline-pretreated mice exposed to 40 and 50 ppm NO2 showed a significant increase. There was a significant increase of Fe content in lung at 15 ppm NO2 exposure. Zn pretreatment inhibited significantly the augmentation of Fe content in lung exposed to 15 ppm NO2. The Cu content in lung after 35 ppm NO2 exposure had incraesed significantly and the rise was depressed by Zn pretreatment. The Mg content in serum after NO2 exposure increased relative to the control value, while the Ca content decreased remarkably. Zn pretreatment protected against the augmentation of pulmonary Ca content ad the drop of serum Ca content. It is considered that Zn depresses the influx of serum Ca to lung caused by NO2 exposure. As well as lung wet weight, the ratio of Ca content in serum to that in lung can be used as a measure of the effect of Zn against lung edema caused by NO2 exposure.
