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Online ISSN : 1883-6879
Print ISSN : 0914-0077
ISSN-L : 0914-0077
Multiple deployment of metallic stents in hilar biliary strictures is safe and effective in the treatment of unresectable cholangiocarcinoma
Hirofumi Kawamoto, Etsuji Ishida, Masakuni Fujii, Tsuneyoshi Ogawa, Koichiro Tsutsumi, Ryo Harada, Hironari Kato, Ken Hirao, Naoko Kurihara, Osamu Mizuno, Kazuhide Yamamoto
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Keywords: malignant hilar biliary strictures, metallic stent, biliary tract carcinoma, chemotherapy
JOURNAL FREE ACCESS

2008 Volume 22 Issue 5 Pages 624-631

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Abstract
Multiple deployment of metallic stents (MS) in hilar biliary strictures still remains controversial in the chemotherapy of unresectable cholangiocarcinoma. Between 1999 and 2006, 46 patients were allocated to the chemotherapy group (n=31; CHT-group) and to the best supportive care group (n=15; BSC-group). Survival time, patency time of MS, and complications were compared between them. Multivariate analysis disclosed that the chemotherapy contributed to the elongation of survival (HR0.36; 95%CI 0.14-0.91). The median survival time is 420days in CHT-group and 190days in BSC-group (P<0.05). Cholecystitis (n=3) and liver abscess (n=1) occurred as complications in CHT group, and hemobilia due to pseudoaneurysm in BSC-group. Multiple deployment of metallic stents in hilar biliary strictures is safe and effective in the treatment of unresectable cholangiocarcinoma.
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© 2008 Japan Biliary Association
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