Abstract
A 73 year old man visited to his family doctor complaint of fever and abdominal pain. Diagnostic imagings revealed cholecystitis and choledochitis with gallstone and gallbladder tumor. He had laparoscopic cholecystectomy. Immuno-hisitochemical examination of the gallbladder tumor revealed Cynaptophysin (+), Chromogranin A (-), CD56 (-) and LCA (-), which comfirmed small cell carcinoma. He had moved to our hospital to have second operation, wedge resection of gallbladder bed and regional lymphadenectomy. However, adjuvant chemotherapy of gemcitabine and TS-1 was given second operation, he died of the disease 8 months after first operation. Small cell carcinoma of the gallbladder is very rare and its prognosis is extremely poor. Operative method or chemotherapy for the disease has not been established. One case was reported long survived after pancreaticoduodenectomy, another was reported to have good response by chemotherapy for lung small cell carcinoma. Further research is needed.
