Abstract
We performed bacteriological analysis of bile in Acute cholecystitis (AC) patients graded in severity according to the guidelines, and also analyzed the risk factors for bactibilia according to whether bacteria were present or absent. One hundred sixty-three AC patients who underwent cholecystectomy plus bacteriological analysis of bile were enrolled. The AC severity was classified as Mild 28 cases (17.2%), Moderate 70 cases (42.9%), and Severe 65 cases (39.9%). In the analysis of high risk factor of bactibilia, more severity grade, elderly cases, elevated body temperature, high CRP, and severe local inflammation were significant risk factor for bactibilia. The prevalence of bactibilia differed significantly between three grades (Mild: 28.6%, Moderate: 55.7%, Severe: 75.4%, P=0.0003). Our local antibiogram showed a higher antimicrobial resistance rate of Enterococcus faecium, Klebsiella pneumoniae, Enterobacter cloacae, and Pseudomonas aeruginosa. In conclusion, adequate antimicrobial therapy perioperatively should be administered according to the bacteriological analyses in bile.
