Abstract
Undifferentiated carcinoma of gallbladder is rare and has a poor prognosis. We report a case of undifferentiated carcinoma of gallbladder suspected by EUS-guided FNA, and diagnosed by autopsy. 85-year-old woman presented with right hypochondralgia and palpable bulky tumor. Abdominal CT scan, MRI and US showed a tumor over 10 cm in diameter with necrosis within. There was no indication for surgery because of age and extent of the tumor. We performed EUS-guided FNA. Histopathological findings were suspicious of undifferentiated carcinoma of gallbladder. We performed endoscopic stent placement for duodenal stenosis caused by rapid growth of the tumor. The patient developed perforation of stomach 24 days after the stent placement, and died 31 days after the procedure. EUS-FNA may be able to make the diagnosis gallbladder carcinoma. However, it is extremely difficult to make the diagnosis of undifferentiated carcinoma, due to the necessity of several samples for the confirmation of the diagnosis. Most undifferentiated carcinoma of gallbladder is unresectable. Moreover, resected cases have a low survival rate. It is necessary to establish multidisciplinary treatment by accumulation of cases.
