A case with gallbladder carcinoma including fat tissue and calcified component

Abstract

A 71-year-old man was diagnosed as having a polyp in the gallbladder by US 2 years ago. He was referred to our hospital for work-up because of the growth of the polyp. Various imaging modalities revealed that the lesion in the size of 20 mm had almost smooth margin and fat component in the center, while the lesion partially had irregular mucosa, thick stalk and notch in the fundus of the gallbladder. Considering gallbladder cancer based on the latter, we performed the total resection of the gallbladder with the gallbladder fossa. Pathological findings of the resected specimen showed the lesion was gallbladder carcinoma with fat tissue and calcified component which is very rare and difficult to diagnose before surgery. The remarkable fibrous change and proliferation of irregular vessels were found around carcinomatous glands in the center. The subserosal tissue with fat in the fundus of the gallbladder was dragged toward the carcinoma accompanied with inflammation, which would cause the fat tissue in the carcinoma.