Premalignant and pre-invasive lesions of biliary tract carcinoma Proposal from WHO 2010 classification with respect to pathological aspects in general rules of biliary tract carcinoma 6^th edition

Abstract

Several revisions were made in the pathology of intrahepatic cholangiocarcinoma and extraheaptic bile duct carcinoma in 2010 WHO classification of tumor of digestive tract. Three types of their early or preneoplastic lesions were added. As for intrahepatic and extrahepatic cholangiocarcinoma, biliary intraepithelial neoplasm (BilIN), intraductal papillary neoplasm, and mucinous cystic neoplasm (MCN) were added, and these lesions were categorized into three grades. As for gallbladder carcinoma, BilIN, intracystic papillary neoplasm, MCN and adenoma were described. In the pathological aspects in general rules of biliary tract carcinoma 6^th edition, these concept and grades of preneoplastic and early neoplastic lesions of WHO 2010 were adopted.