Abstract
Localization of cancer is critical to perform local excision for polyp type ampullary cancer (pAC). Imaging diagnosis is, however, limited in exactly identifying the tumor location. We studied four cases of pAC to determine whether or not preoperative identification of tumor location, subtypes, and malignancy potential was possible. All cases were early cancer. In three of four cases (Cases 1, 2, and 4), the tumor was located from the duodenum to the common channel of the major duodenal papilla, and the remaining cases were localized in the duodenum throughout the duodenal papilla only in Case 3. Expression of CK7, CK20, and CD10 was observed by staining of the resected tissues in Cases 1, 2, and 4, while only CK20 and CD10 expression were observed in Case 3. In preoperative biopsy tissues, only the results of CK7 staining in Case 4 were significantly different from the resected tissue. Other preoperative biopsy tissues were consistent with the staining behavior of resected tissues. MUC1 and MUC2 staining indicated intestinal type with better prognosis in all cases. In conclusion, CK7, CK20, CD10, MUC1, and MUC2 staining in preoperative biopsy tissues could provide information on the tumor location, subtypes, and malignancy potential in pAC.
