2015 Volume 29 Issue 2 Pages 219-225
Five words, "Forty", "Female", "Fatty", "Fair", "Fertile" are often recognized as the risk factor for gallstone. Also, it is reported that gallstone correlates with lipid abnormalities and diabetes mellitus. Recently, the changes of Japanese basic life style resulted in the increase of obesity, diabetes mellitus and lipid abnormalities, therefore, we attempted to clarify the risk factors for gallstone in this situation. We divided our 205 gallstone patients into three groups by Tsuchiya's gallbladder stone classification, and made the analysis about age, sex, BMI, serum lipids, fasten plasma glucose, HbA1c and insulin. People who have Tsuchiya type 1 gallstone (recognized as cholesterol gallstone) show the features: obese and having insulin resistance, when compared with the other gallstone group and stone free group. Moreover, multivariate statistics shows "age" and "obesity" are the significant risk factors. These results suggest that cholesterol gallstone formation is promoted by obesity or increase of insulin resistance.
