2015 Volume 29 Issue 2 Pages 254-260
A 71-year-old woman with a complaint of right hypochondralgia was referred to our hospital and was found to have tumors of the gallbladder and liver by using ultrasonography. She was diagnosed as gallbladder carcinoma with the liver and lymph nodes metastasis by abdominal ultrasonography, CT and MRI. She underwent central bisectionectomy of the liver, as well as cholecystectomy and resection of the extrahepatic bile duct with lymph nodes dissection. Histopathologic examination revealed that the tumor consisted of small, nodular-infiltrative carcinoma cells in the gallbladder and the liver. Immunohistochemical examination revealed that the carcinoma cells were positive for Synaptophysin and that Ki-67 labeling index was 95%. The definitive diagnosis was neuroendocrine carcinoma. Three months after the surgery, CT revealed that she had multiple recurrences in the liver, and she died 1 month later. Neuroendocrine carcinoma of the gallbladder is thought to have a poor prognosis, so effective multidisciplinary treatment including surgery with lymph nodes dissection and adjuvant chemotherapy must be required for this disease.
