A case of nivolumab-induced cholangitis with diffuse wall thickening of the bile duct and gallbladder

Abstract

An 81-year-old woman, who was treated with nivolumab monotherapy, was referred to our department because of high levels of biliary tract enzymes, detected on performing a blood test. Computed tomography and endoscopic ultrasound showed diffuse wall thickening of the bile duct and gallbladder. Endoscopic retrograde cholangiography revealed extrahepatic bile duct dilation without obstruction. Nivolumab-induced cholangitis was diagnosed and she received steroid therapy. After steroid therapy, both the levels of biliary tract enzymes in blood and the diffuse wall thickening of the bile duct and gallbladder decreased.