Hepatoid adenocarcinoma of the gallbladder

Abstract

A 71-year-old female was referred for further examination of a gallbladder tumor. Blood test revealed elevated levels of γ-GT, AFP and AFP-L3%. Contrast-enhanced computed tomography revealed an enhanced irregular wall thickening lesion in the fundus and body of the gallbladder. Although histological diagnosis was not obtained, we strongly suspected gallbladder cancer based on the imaging findings. Cholecystectomy and hepatic S4a+S5 resection, bile duct resection, regional lymphadenectomy were performed. A 70×50×45-mm massive type tumor was located at fundus and body of the gallbladder. Histologically, the tumor was composed of hepatoid cell and adenocarcinoma. Hepatoid cells were stained for AFP, hepatocyte parafine-1, Arginases. Pathological diagnosis was hepatoid adenocarcinoma (HAC) of the gallbladder. We have present a rare case of HAC of the gallbladder with review of literature.