2020 Volume 34 Issue 1 Pages 7-13
The reason I became interested in biliary tract was the clinical research "Change of free radicals during obstructive jaundice". Superoxide dismutase generated at obstructive jaundice was measured, and it was examined whether it was possible to distinguish a group with poor reduction of jaundice. At the time of obstructive jaundice, the outflow of activated neutrophils into peripheral blood accompanying the increase in the ability to produce active oxygen was promoted. In addition, lipid peroxide in the obstructive jaundice group showed a high value, and it was considered that hepatocyte function was reduced due to increased lipid peroxide production activity in the liver. I was able to get involved in national biliary tract cancer registry and revision of classification of biliary tract cancer. The number of registered cases became big data of 35225 cases. In a study of biliary tract cancer registration, hepatectomy of the S4a+5 segment and gallbladder bed resection for T2 gallbladder carcinoma were compared, and there was no significant difference in prognosis. In addition, a study of the national biliary tract cancer registration and UICC staging showed that gallbladder cancer should include the 13a lymph node in the regional lymph node. The biliary tract cancer registry will be transferred to NCD along with the revision of classification of biliary tract cancer (7th edition), and preparations are being made to accumulate more cases.
