2021 Volume 35 Issue 1 Pages 79-86
81-year-old man had complaints of jaundice and fever, and was diagnosed with distal cholangiocarcinoma the result of enhanced CT and the biopsy with ERC. The surgical treatment was performed, and tumors showed adenocarcinoma in the biliary epithelium, and neuroendocrine carcinoma in the submucosal infiltrating lesion. Adenocarcinoma components and neuroendocrine carcinoma components accounted for more than 30% each, and the diagnosis was mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). After the operation, the chemotherapy was performed, but died after 20 months. MiNEN of bile duct is difficult to differentiate before operations. The gold standard treatment for this disease has not been established and not only surgical treatment but also multimodal treatment such as preoperative chemotherapy may be considered.
