2022 Volume 36 Issue 5 Pages 626-632
A 75-year-old woman had received 2 months of chemotherapy with gemcitabine and nab-paclitaxel for pancreatic ductal carcinoma. During the treatment, she presented with abdominal pain and elevated liver enzymes. Even after the chemotherapy was discontinued, the symptoms continued and she was admitted. ERC revealed dilatation of the bile duct and no biliary obstruction. Changes like shaggy appearance were visible at bile duct wall. She was diagnosed as an eosinophilic cholangitis based on eosinophil infiltration in the biliary duct wall of the biopsy sample. The liver enzymes and abdominal symptoms were normalized after the administration of an oral steroid. After the normalization, She showed no major side effects during the chemotherapy with gemcitabine monotherapy. These results raised a suspicion of eosinophilic cholangitis caused by chemotherapy with nab-paclitaxel. To the best of our knowledge, there few reports of eosinophilic cholangitis caused by chemotherapy with nab-paclitaxel. We report with literature review discussion.
