Two cases of Pancreaticobiliary Maljunction in Monozygotic twins

Abstract

The first case was a female in her 50s. US for surveillance of chronic hepatitis C showed gallbladder wall thickness. MRCP and EUS showed pancreaticobiliary maljunction (PBM) without biliary dilatation. The second case was a female who was the sister of monozygotic twins in first case. She was recommended to be examined by her sister's doctor, and US also showed gallbladder wall thickness. As a result, PBM without biliary dilatation was found. Laparoscopic cholecystectomy was performed in both cases and hyperplastic changes were observed in the resected gallbladder mucosa, but there were no malignancy. There have been few reports of familial occurrence, and our case is the third case of co-occurrence in monozygotic twins. Our case was interesting because it suggests the possibility of familial occurrence. Screening of families with PBM may be remarkable.