2025 Volume 39 Issue 2 Pages 189-195
We investigated the differences among patients with distal bile duct cancer with severe pancreatic invasion and were preoperatively diagnosed with pancreatic head cancer (Pre-PDAC group), patients with typical distal bile duct cancer (BDC group), and patients with pancreatic head cancer (PDAC group). Among 69 patients with distal bile duct cancer, 15 (21.7%) did not undergo surgical resection, and 54 (78.3%) underwent pancreaticoduodenectomy. Among the resected cases, 9 (16.7%) were classified as Pre-PDAC. The median survival time (MST) in the Pre-PDAC group was 20.9 months, significantly poorer than 106.8 months in the BDC group. No significant difference in MST was observed between the non-resected group (12.0 months), the Pre-PDAC group (20.9 months), and the PDAC group (32.9 months). The 2-year relapse-free survival rate was significantly lower in the Pre-PDAC group (25.0%) than in the BDC group (60.0%), and liver metastasis was frequently observed upon recurrence.
