Abstract
67 year-old-female was admitted to our hospital because of right subcostal pain. She was diagnosed as gallbladder cancer associated with the invasion directly into duodenal bulbus and liver by the examination of ultrasonography, CT, angiography, fiberscopy and so on. She underwent operation resected the tumor involved liver (S4+5), choledochus, duodenal bulbus and was performed lymphadenectomy. Pathological stage was stage IV (si; duodenum, hinf3, binf3, n2). Although almost all the part of tumor histologically consisted of well differentiated squamous carcinoma, there was signet cell carcinoma in the extremely little part of tumor. And the same findings were shown in the metastatic lymph node (No.12b). Pathological findings and the results of Keratin staining showed that signet cell carcinoma partly involved the characteristics of squamous carcinoma. In conclusion it was suggested that there was the possibility which might cause the rechange that squamous carcinoma would change to adenocarcinoma maintainning the feature of adenocarcinoma although adenocarcinoma in this case had changed to squamous carcinoma.
