Abstract
A 48-year old female was admitted to our hospital complaining of upper abdominal fullness and abdominal mass. Abdominal US and CT revealed a mass showing extragrowth from the fundus of the gallbladder and liver metastases. Angiography showed hypervascular tumors. ERCP showed stenosis of the upper bile duct and pancreatobiliary maljunction. Biopsy specimen from the liver tumor was diagnosed histologically undifferentiated carcinoma showing immunoreactivity for NSE. Administration of cytostatics, such as CDDP (cisplatin) and VP-16 to this patient resulted in the tumor shrinkage for a while, however, the patient died 16 months after the first admission. Autopsy revealed gallbladder tumor markedly invaded to surrounding organs. Microscopic examination revealed admixed proliferation of adenocarcinoma and endocrine tumor, and the tumor was diagnosed as endocrine cell carcinoma of the gallbladder.
