Abstract
We studied histopathologically 6 autopsied patients with biliary carcinoma (3 gallbladder carcinoma and 3 bile duct carcinoma) treated with self-expandable metallic stent after combined therapy of local hyperthermia, chemotherapy and radiotherapy. The stent encroached into the membranous and submembranous layer and expanded the muscular layer of the bile duct. The lumen of the stent was nonpatent in 3 cases, and neoplastic proliferation across the mesh of stent (ingrowth) was detected in 3 cases. Stent was partly obstructed with debris or necrotic mass, however, no complete obstruction with carcinoma was detected. Extensive fibrosis, necrosis or granulation tissue were detected in the wall of the bile duct, which might be induced by the effect of combined treatment.
Placement of self-expandable metallic stent into the patency-restored bile duct of the biliary carcinoma after combined therapy is useful for keeping the longer patent period of the duct.
