Abstract
In order to reveal the causes of bile duct dilatation, we attempted to make the models of canine dilated bile duct. Following four models which are claimed to produce bile duct dilatation are examined.
1) narrowing the lower common bile duct lumen by taping plastic tube
2) formalin injection into papillary mucosa
3) stripping common bile duct
4) sphincterotomy
Dilatation of common bile duct could be produced successfully in the first three groups and not in the last group which used sphincterotomy.
The severe bile stasis was observed by cholangiomanometry in group 1 and 2. The bile dilatation in these groups is considered to be caused by increase of intraductal pressure. In group 3, bile duct dilatation occured in spite of abscence of bile stenosis. Cholangiomanometry showed normal range for this group. Weakness of bile duct wall and surrounding tissues probably causes bile stasis.
From the above results, it is possible to divide the methods which experimentally produce bile duct dilatation into two groups. One method is to disturb biliary passage such as papillary stenosis or bile duct stenosis. Another one is to strip bile duct without any stenosis.
