Abstract
Forty-eight year-old female was admitted to the hospital with chief complaints of vague epigastric pain and weight loss of 4 kg. At the time of admission, WBC count was 52,500/mm3and eosinophil count was 15,250/mm3 (29%). No morphological abnormality was found in examinaton of the bone marrow. There was no history of allergies, asthma or skin diseases. She had never traveled outside of Japan. Serum Ig-E level was normal and antibodies to parasites were negative. Multiple liver metastasis was found by image diagnosis. Intra-arterial injection of 20 mg of mitomycin C was performed by the route of celiac angiography. Eosinophil didn't decrease in count.
Adenoca r c inoma cells were found in ascites and intraperitoneal administration of 2 mg of mitomycin C was performed, then eosinophil count decreased from 38,500/mm3 to 2,609/mm3. Autopsy revealed that gallbladder cancer showed no eosinophilic infiltration while hyperplasia of eosinophils without chromosomal abnormalities was found in bone marrow. Accordingly, eosinophilia might be caused by stimulator of eosinophil-colony growth released from gallbladder cancer.
