Pathophysiology of cases with high output of bile reviewed from bile analysis

Abstract

Bile analysis was evaluated to examine the pahophysiologyy of 14 cases with high output of bile. These cases were characteristic of increasing of volume per day of HCO3, Cl^-, and Na⁺, and concentration of HCO3 and Cl^- in bile. On the other hand, one group with the bad efficacy of bile drainage in these cases was injured bile acid and bilirubin secretion, but volume per day of HCO3, Cl^- and Na⁺, and concentration of HCO3 and Cl^- in bile increased more than the other group with the good efficacy. For the above, it is suggested that ductular bile secretion, which is very similar to the choleretic mechanism of sccretin, increases in cases with high output of bile. Furthermore, it is speculated that in one group with the bad efficacy of bile drainage, canalicular bile secretion is damaged but ductular bile secretion more increases to supply the damaged canalicular bile secretion than the other group with the good efficacy.