Abstract
This study was aimed to clarify prognosis-regulating factors of patients with gallbladder can. cer. One hundred fifty-seven patients with gallbladder cancer microscopically confirmed, in which curative resection was performed, were subjected to this study.
Generalized Wilcoxon's test demonstrated that the d i f ference of postoperative survival rates was statistically significant in the degree of depth of cancer infiltration (p<O.05), hepatic infiltration (p<0.05), the infiltration of hepatoduodenal ligament (p<0.05), lymph node metastasis (p< 0.05), histologic type (p<0.05), lymphatic invasion (p<O.05), venous invasion (p<0.05)and perineural invasion (p<0.05).
Cox's proportional hazards m odel demonstrated that the degree of depth of cancer infiltration (chi square 9.4762) and perineural invasion (chi square =5.2697) are good indicators to identify the group of patients with a high risk of cancer death. Especially, in the patients with gallbladder cancer invading the submucosal layer, Cox's proportional hazards model demonstrates that lymph node metastasis (chi square = 4.0627) and perineural invasion (chi square =4.1447)are good indicators to know the patients with a high risk of cancer death.
I concluded that the degree of depth of cancer infiltration, peri n eural invasion and lymph node metastasis are very important factors to predict the prognosis of patients with gallbladder cancer.
