Survey on delirium in allogeneic hematopoietic cell transplant patients at our hospital

Abstract

 [Purpose] In Japan, there is not enough research on delirium in allogeneic hematopoietic cell transplantation (HSCT) patients. This study aims to evaluate delirium among allogeneic HSCT patients at our hospital. We compared the risk factors, such as hypoxia, opioid use, and renal and hepatic dysfunction, of the delirium and non-delirium groups. [Results] The incidence of delirium within 30 days of transplantation was 30.3% (of which onset within 14 days was observed in 70%). Oxygen administration, opioid use, abnormal BUN, CRE, and Bil were more frequent in the delirium group: 70% and 19.6%, 70% and 60.9%, 85% and 39.1%, 65% and 26.1%, and 80% and 39.1% in the delirium and non-delirium groups, respectively. [Discussion] The incidence of delirium tended to be higher within 14 days after transplantation, which is the standard period for engraftment. Because of the intensive physical invasion of patients during this period, it is difficult to differentiate between decreased patient activity and hypoactive delirium. It is crucial to be aware of the risk factors of delirium specific to allogeneic transplant patients and the timing of care.