2024 Volume 13 Issue 4 Pages 104-112
Advances in managing viral infections in allogeneic hematopoietic stem cell transplantation have contributed to improved patient outcomes. However, several unresolved challenges remain. This review will focus on the following key topics: 1) the current status of vaccines for preventing varicella-zoster virus infections, 2) the association between reactivation of cytomegalovirus and relapse rates of acute myeloid leukemia, 3) the impact of HHV-6B reactivation on the central nervous system, 4) cases of HHV-6B encephalitis following chimeric antigen receptor T-cell therapy and their clinical significance, and 5) the challenges in diagnosing post-transplant viral infections and efforts to improve detection rates using diagnostic methods such as multiplex PCR and next-generation sequencing. The review will discuss these insights and explore future perspectives.
