Current status of diagnosis and treatment of late onset SOS

Abstract

 Sinusoidal obstruction syndrome (SOS) is one of the major complications after hematopoietic cell transplantation and is fatal in severe cases. The modified Seattle and Baltimore criteria have been used for many years. New diagnostic criteria were proposed by the European Society for Blood and Marrow Transplantation (EBMT, European Society for Blood and Marrow Transplantation) in 2016 and subsequently, its revised version was published in 2023. This article discusses the current status and future challenges of late onset SOS as proposed by the EBMT diagnostic criteria.