57(P-29) The Antibacterial Compound related to the pathogenesis of Dermatitis, isolated from Polygonum tinctorium
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The yeast Malassezia furfur, present in the normal microflora on human skin, has been known to cause several skin diseases: tinea versicolor, Malassezia folliculitis, seborrheic dermatitis, psoriasis. Recently it has received much attention that M. furfur was reported to be closely related to atopic dermatitis (AD), because it has been observed in patients with head and neck AD and nine allergens have been found from it. On the other hand, in China, Korea and Japan the indigo plant, Polygonum tinctorium, has been used in traditional folk medicine for detoxicatipn, antipyrexia, anti-nociception, anti-inflammation and especially dermatopathy. Interesting in this plant correlated with the effect in dermatopathy, we have searched an antibacterial compound against M. furfur. Finally the high active compound has been isolated and identified as Tryptanthrin.
