Heat Properties of Magnetoliposomes for Local Hyperthermia

Abstract

The magnetoliposomes for hypertermia of cancer were developed. These were prepared by the coating of a phospholipid to the magnetite fine particles. The magnetoliposomes generated heat in the high frequent magnetic field. The heat evolution rates of the magnetoliposomes varied with core magnetite's size. When the magnetite's size was 40nm, the heat evolution rate was highest. Hyperthermia simulation using the magnetoliposomes was performed according to concentric spherical tumor perfusion model with a necrotic core surrounded by intermediately and highly perfused shells of blood. When 45.5 kA/ m (572 Oe) of magnetic field and 240 kHz of frequency were applied, 0.74mg/cm³-tissue of the magnetoliposomes were simulated to be necessary for heating tumor tissue of 6 cm in diameter to 42-45°C.