Proceedings of Workshop on “Current Topics of Hyperthermia Oncology”
Antitumor Agents and Hyperthermia
1986 Volume 2 Issue 2 Pages 80-85
Details
1986 Volume 2 Issue 2 Pages 80-85
The effect of hyperthermia on adriamycin cytotoxicity toward cultured cells was varied with the cell lines used; In human carcinoma cell line HeLa and KB, cell killing of adriamycin increased at 42 and 43°C, but in Chinese hamster ovary cells (CHO) and SV40-transformed rat fibroblasts (W3Y), the cytotoxicioy was decreased at the elevated temperatures. Heating CHO and W3Y cells at 43°C induced a resistance to adriamycin cytotoxicity in subsequent drug treatment at 37°C. The cytotoxic effect of peplomycin was increased by 43°C hyperthermia, but the enhancing effect was very much decreased in thermotolerant cells. On the other hand, verapamil equally enhanced peplomycin cytotoxicity in unheated and thermotolerant cells. Benzaldehyde and its derivatives are not cytotoxic at 37°C, but the combination with hyperthermia greatly enhanced the cytotoxicity in transformed cells rather than untransformed cells.
