Clinical Results of Hyperthermia Treatment by 915 MHz Microwave Heating
1988 Volume 4 Issue 2 Pages 139-149
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1988 Volume 4 Issue 2 Pages 139-149
The 915 MHz microwave hyperthermia system Clini-therm Mark IX was introduced in Hokkaido university hospital in September 1986 and 33 patients were treated using this system until july 1987. Hyperthermia was given once or twice weekly for 60 minutes at 43 °C using direct contact applicators. In most of the cases hyperthermia was combined with radiation therapy. Other combined therapies were chemotherapy and I-131 therapy.
The materials evaluated were 18 patients who had more than 6 fractions of hyperthermia, more than 3 months' follow-up period and were combined with irradiation. Tumor volume response were : CR= 28%, PRa=39%, PRb=11%, NC=22%.
In analysis of intratumoral temperature, the tumor edge temperature and the uniformity of heating were correlated with the tumor response, which suggests the minimum intratumoral temperature is important for the evaluation of hyperthermic effect to the tumors.On the other hand the maximum intratumoral temperature appeared to be correlated with heat-induced toxicities.
