1990 Volume 6 Issue 1 Pages 51-67
The efficacy of thermochemotherapy was examined by using solid Yoshida Sarcoma implanted on the feet of rats. Water bath treatment was applied for heating. With heat treatment alone, 42-44°C induced significantly tumor growth suppression. At 45°C, the tumor size was reduced significantly. Treatment with MMC alone reduced significant tumor growth. 42°C or 43°C heating combined with 1 mg/kg MMC induced complete tumor regression which was not obtained through heating alone or chemotherapy with MMC alone.
Histopathologically, central necrosis, fibrinous thrombus and obliteration of the blood vessels were observed on the 5th day after heating at 42°C and over. Severe necrotic changes such as coagulating necrosis of the deep seated striated muscle were observed with 45°C heating on the 5th day. A small number of viable tumor cells remained surrounding the necrotic lesion on the 5th day after treatment with 1 mg/kg MMC alone, however, necrotic or degenerative tumor cells with pyknosis of the nuclei were found strikingly.
The histopathological findings with thermochemotherapy showed remarkable changes such as complete tumor necrosis as compared with either heating alone or MMC alone.
The efficacy of thermochemotherapy was synergistic.
