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Tropical Medicine and Health
Vol. 39 (2011) No. 4SUPPLEMENT P S73-S81

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http://doi.org/10.2149/tmh.2011-S08

Reviews

Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options.

Copyright © 2011 by The Japanese Society of Tropical Medicine

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