Tropical Medicine and Health
Online ISSN : 1349-4147
Print ISSN : 1348-8945
ISSN-L : 1348-8945
Reviews
Host genetic susceptibility to severe dengue infection
Nguyen Thi Phuong LanKenji Hirayama
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2011 Volume 39 Issue 4SUPPLEMENT Pages S73-S81

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Abstract

Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options.

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© 2011 by The Japanese Society of Tropical Medicine
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