LOCALIZATION OF TOXOPLASMA GONDII ANTIGENS IN DENSE GRANULES AND RHOPTRIES DETECTED BY SERA FROM CONGENITAL TOXOPLASMOSIS PATIENTS

TATSUYA TEGOSHI; SHINJI MATSUDA; TAKASHI HAYANO; YOSHITSUGU MATSUMOTO; MINORU YAMADA; TSUNEZO SHIOTA; AKIO KURODA; NAOKI ARIZONO

doi:10.2149/tmh1973.24.1

LOCALIZATION OF TOXOPLASMA GONDII ANTIGENS IN DENSE GRANULES AND RHOPTRIES DETECTED BY SERA FROM CONGENITAL TOXOPLASMOSIS PATIENTS

TATSUYA TEGOSHI, SHINJI MATSUDA, TAKASHI HAYANO, YOSHITSUGU MATSUMOTO, MINORU YAMADA, TSUNEZO SHIOTA, AKIO KURODA, NAOKI ARIZONO

Author information

TATSUYA TEGOSHI
Department of Medical Zoology, Kyoto Prefectural University of Medicine
SHINJI MATSUDA
Department of Medical Zoology, Kyoto Prefectural University of Medicine
TAKASHI HAYANO
Division of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine
YOSHITSUGU MATSUMOTO
Department of Medical Zoology, Kyoto Prefectural University of Medicine
MINORU YAMADA
Department of Medical Zoology, Kyoto Prefectural University of Medicine
TSUNEZO SHIOTA
Department of Medical Zoology, Kyoto Prefectural University of Medicine
AKIO KURODA
Department of Medical Zoology, Kyoto Prefectural University of Medicine
NAOKI ARIZONO
Department of Medical Zoology, Kyoto Prefectural University of Medicine

JOURNAL FREE ACCESS

1996 Volume 24 Issue 1 Pages 1-4

DOI https://doi.org/10.2149/tmh1973.24.1

Details

Abstract

Subcellular antigen localization in Toxoplasma gondii was studied by immunoelectron microscopy using sera obtained from congenital toxoplasmosis neonates or the mother. IgG and IgM antibodies bound specifically to the dense granules and rhoptries, but little bound to the cytoplasm of the organism or its tegmentum. The results indicate the importance of dense granules and rhoptries as a storage site for the antigens, which would be released and stimulate antibody production in human toxoplasmosis.

Corresponding author

Register with J-STAGE for free!