Abstract
Exclusive therapy with sulfamonomethoxine, exclusive therapy with chloroquine, and the therapy with the combination of sulfamonomethoxine and pyrimethamine have individually been applied to 118 patients with malaria in Laos, and the effects were comparatively evaluated on the basis of quantitative progress in asexual parasitemia. The results are summarized as follows :
1) The presence of chloroquine-resistant type of malaria was suspected. 2) It was confirmed that sulfamonomethoxine has therapeutic efficacy comparable to that of chloroquine. 3) The therapeutic efficacy of sulfamonomethoxine was of a delayed type. 4) The combination of sulfamonomethoxine and pyrimethamine showed 100% effectiveness in the disappearence of parasitemia on blood film. 5) The following method was established on the ground of the above findings for the prophylaxis and therapy of malaria : For prophylaxis of malaria, 500 mg of sulfamonomethoxine should be administered twice a week, provided that the MP-therapy is at any time available. For the treatment of malaria, exclusive therapy with sulfamonomethoxine should be used as the first choice, and the progress in the number of asexual parasitemia should be observed for at least one week while this therapy is being applied.
Until the number of asexual parasitemia increases or is found to remain unexpelled even one week after its administration, no other therapy such as chloroquine or the combination of sulfamonomethoxine and pyrimethamine should be applied.
