2009 Volume 34 Issue 4 Pages 711-713
Recent increases of allergenic diseases are tremendous. Multiple chemical ingredients may possibly be the allergens or deteriorants. We chose the daily used products mainly applied on the skin. This paper shows the safe and proper application of Hinokithiol as for the antiseptics and preservatives.
Hinokithiol (synthetic one, and natural one derived from Aomori-Hiba dissolved in alcohol and Tween, whose concentrations were 0.1%, 0.05%, 0.005%) were patch-tested on 15 healthy adults. Stimulation Indices (SI) were analyzed both after 48 hours and 72 hours. Synthetic Hinokithiol showed the mean SI 11.6 after 48 hours and 4.5 after 72 hours. Natural Hinokithiol dissolved in alcohol showed SI 6.6 after 48 hours and 2.2 after 72 hours. SI by Hinokithiol dissolved in Tween showed 0. For the daily use of products applied on the skin, natural ingredients rather than artificial (synthetic) ones are safer for the skin, especially for allergic patients.
