Abstract
Quaternary ammonium functionalized radial compounds n-C10I (n = 3, 4, 8, 16), n-C10Br (n = 3, 4) and their reference non-radial compounds 1-C10X (X = Br, I) were synthesized and their antibacterial properties for gram-positive bacteria (Methicillin-resistant Staphylococcus aureus; MRSA) and gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) were investigated. The antibacterial activity for tested bacteria depended on the number of the terminal quaternary ammonium unit, and the influence of the counter anion for antibacterial activity was not observed. The antibacterial activity of 3-C10X (X = I, Br) for MRSA was the highest in tested bacteria.
