Transactions of the Materials Research Society of Japan
Online ISSN : 2188-1650
Print ISSN : 1382-3469
ISSN-L : 1382-3469
Regular Papers
Antibacterial Activity of Radial Compounds with Peripheral Quaternary Ammonium Units
Jun KawakamiIsao HaradaAkio NakaneHaruo KitaharaMasahiko NagakiShunji Ito
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2010 Volume 35 Issue 4 Pages 885-887

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Abstract

Quaternary ammonium functionalized radial compounds n-C10I (n = 3, 4, 8, 16), n-C10Br (n = 3, 4) and their reference non-radial compounds 1-C10X (X = Br, I) were synthesized and their antibacterial properties for gram-positive bacteria (Methicillin-resistant Staphylococcus aureus; MRSA) and gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) were investigated. The antibacterial activity for tested bacteria depended on the number of the terminal quaternary ammonium unit, and the influence of the counter anion for antibacterial activity was not observed. The antibacterial activity of 3-C10X (X = I, Br) for MRSA was the highest in tested bacteria.

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© 2010 The Materials Research Society of Japan
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