Preparation of 12-hydroxystearic acid microsphere containing oil-based contrast medium

Abstract

For efficient transcatheter arterial embolization therapy, we have developed 12-hydroxystearic acid (HSA) microspheres containing mixtures of Canola oil and oil-based contrast medium, Lipiodol, as obstructing materials. The diameters of the obtained microspheres were in the range between 50 and 200 μm. The X-ray CT value for the microsphere suspensions was controlled by the mixing ratio of Canola oil and Lipiodol; The Lipiodol concentration range between 20% and 40 % corresponds to ca. 1000 HU that is favorable to avoid artifacts.