Use of Polymer-Supported Terpyridine Palladium Complex for Suzuki–Miyaura Cross-Coupling Reaction in Water and the Synthesis of 2,6-Disubstituted Pyrimidines

Abstract

  In this study, a polymer-supported terpyridine–palladium complex was prepared and found to promote the Suzuki–Miyaura cross-coupling reaction in water. The terpyridine ligand was prepared from 4-methoxycarbonylbenzaldehyde, 2-acetylpyridine according to the reported procedures. The terpyridine ligand was immobilized onto a PS-PEG resin, and the complexation of the PS-PEG terpyridine ligand with Pd(II) gave the PS-PEG terpyridine–Pd(II) complex. The polymeric catalyst showed high catalytic activity and high reusability for this cross-coupling reaction. This catalyst was also applied to the synthesis of 2,6-disubstituted pyrimidines in water.