Abstract
We studied the influence of glycemic control on residual beta cell function in patients with acute-onset type 1 diabetes mellitus. Subjects were 20 patients who met diagnostic criteria for acute-onset type 1 diabetes proposed by the committee of the Japan Diabetes Society, and who were medicated from the onset at our center. Beta cell function of these patients was evaluated by annual glucagon stimulation tests. The rate of decrease in the glucagon stimulated serum C peptide from the first glucagon stimulation test to the second test, correlating significantly with average HbA1c from the first to the second test (r=0.448, p<0.05, n=20). The rate of decrease in that from the second to the third test was not significant due to few subjects (n=9), but tends to correlate with average HbA1c from the second to the third test (r=0.619, p=0.075). These results suggest good glycemic control may have a beneficial effect on preserving residual beta cell function in patients with acute-onset type 1 diabetes.
