Abstract
We retrospectively studied clinical risk factors in chronic diabetic complications in 166 long-term cases followed up over 20 years, evaluating retinopathy and nephropathy severity and the incidence of myocardial and cerebral infarction. We statistically analyzed relationships between clinical parameters-onset age, duration, obesity, hyperglycemia, dyslipidemia, hypertension, and their accumulation-and the above complications with ANOVA, the chi-squared test, and multiple logistic regression analysis. Significant risk factors in retinopathy were hyperglycemia and its duration and hypertension, while those in nephropathy were young onset age, hyperglycemia, dyslipidemia, and hypertension. Cerebral infarction was associated with hypertension. A significant increase was seen in the frequency of complications parallel to the accumulation of metabolic syndrome components-obesity, dyslipidemia, and hypertension in nephropathy but not in vascular events. Resuls suggest that sufficient hypertension treatment is important for preventing diabetic complications and that the accumulation of obesity, dyslipidemia, and hypertension is a risk factor for nephropathy in diabetic patients.
