Abstract
Insulin Lispro Mixture-50 contains 50% insulin lispro, a rapid-acting insulin analog, and 50% insulin lispro protamine suspension, an intermediate-acting component.
To evaluate the effects of Insulin Lispro Mixture-50 three times a day, type 2 diabetic patients already treated with insulin and inadequately controlled (n=28) were assigned to switch from insulin to 3 months of treatment with Insulin Lispro Mixture-50 three times a day. As the endpoint, HbA1c decreased significantly from 8.01% to 7.49% overall. Compared to groups categorized with insulin used before switching, HbA1c improved significantly in the group switching from premixed human insulin twice a day and the group getting Insulin Aspart Mixture-30 three times a day.
Results of a questionnaire on the change of the injector and insulin indicated that it was a good answer for both.
Insulin Lispro Mixture-50 three times a day thus appears to be useful in improving glycemic control.
