Journal of the Japan Diabetes Society
Online ISSN : 1881-588X
Print ISSN : 0021-437X
ISSN-L : 0021-437X
Original Article
Evaluation of Miglitol and Voglibose Effect on Postprandial Plasma Glucose after Test Meal A Loading
Daigaku UchidaSusumu NakamuraTakamichi YamaneShunichiro OnishiSawako SuzukiIchiro Tatsuno
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JOURNAL FREE ACCESS

2008 Volume 51 Issue 5 Pages 411-418

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Abstract
Two alpha-glucosidase inhibitors (α-GIs), acarbose and voglibose, have been used to treat patients with type 2 diabetes in Japan, and a new α-GI, miglitol, became available for clinical use in 2006. Postprandial hyperglycemia and postprandial hyperlipidemia have been found to be closely related to cardiovascular disease. Test meal A was developed to simultaneously evaluate postprandial hyperglycemia and hyperlipidemia.
We evaluated the effects of miglitol and voglibose on postprandial plasma glucose and plasma insulin in 20 patients with type 2 diabetes after test meal A loading. Miglitol strongly suppressed the rapid rise of postprandial plasma glucose 0.5 to 1 hour after meal loading compared to voglibose. Changes and incremental AUC0-120 min of postprandial plasma insulin were decreased more significantly by miglitol than by voglibose.
We concluded that miglitol suppressed the rapid rise of postprandial plasma glucose more markedly than voglibose in type 2 diabetic patients, thus more strongly suppressing endogenous insulin secretion.
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© 2008 Japan Diabetes Society
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