Abstract
This study investigated the interaction between nonalcoholic fatty liver disease (NAFLD) and cardiovascular risk factors in the general health examination cohort. Study subjects included 1,046 people with non fatty liver and 532 with NAFLD based on US scanning and alcohol consumption. Metabolic abnormalities were diagnosed based on metabolic syndrome criteria in Japan. Hyperinsulinemia was defined as the highest quartile of fasting plasma insulin (F-IRI) in subjects with normal fasting plasma glucose (FPG). Multivariate logistic regression model by gender showed that NAFLD was independently related to high TG, low HDL-C, high FPG, and hyperinsulinemia in both genders. After further adjustment for F-IRI, this result was not changed in high TG and low HDL-C in men, but changed in high FPG in both genders. BMI and F-IRI were identified as independent risk factors for NAFLD in both genders. NAFLD was thus suggested to interact directly with dyslipidemia in men, whereas it might interact with glucose metabolism via F-IRI in both genders.
