Abstract
To clarify GAD antibody (GADab) prevalence in Japanese noninsulin-dependent diabetes (NID) and to characterize the clinical GADab-positive NID features, we examined 2,110 NID cases in Osaka Police Hospital from August 2007 to May 2008. Of these, GADab was detected in 39 (1.85% [95%CI 1.27-2.42%]) . Those with high GADab titers (GAD>10 U/ml) (HT-NID) had more typical type 1 diabetes than those with low GADab titers (GAD<10 U/ml) (LT-NID) . No statistically significant difference was seen in fasting serum C-peptide and BMI between LT-NID and typical type 2 diabetes subjects, more LT-NID subjects required insulin therapy (p<0.001) . Pancreatic β-cell function evaluated by SUIT index was significantly lower in LT-NID subjects (p<0.01) . Taken overall, results suggest differences in LT-NID and typical type 2 diabetes pathology.
