Abstract
We analyzed left ventricular (LV) diastolic dysfunction prevalence and features in 142 subjects with type 2 diabetes without valvular disease, atrial fibrillation, or ischemic heart disease history. The E/A ratio before and during the Valsalva maneuver was assessed with pulsed doppler and the E/Ea ratio (early transmitral to early diastolic annular velocity ratio) with pulsed tissue doppler imaging. The ejection fraction exceeded 50% in all subjects. LV diastolic function was normal in 75 (52.8%) and LV diastolic dysfunction found in 67 (47.2%) , of whom 16 (11.3%) showed a pseudonormal pattern. Those with LV diastolic dysfunction were older than those with normal function. Multiple logistic regression analysis showed that age ≥65 years [ (Odds ratio: 5.67 (95% CI, 2.48-12.96) , p<0.0001], resting heart rate ≥70 bpm [ (2.18 (1.02-4.65) , p<0.0441) ], and short-duration diabetes [ (0.49 (0.27-0.88) , p<0.0163) ] were at risk for LV diastolic dysfunction. Those with diastolic dysfunction were older even in their diabetes-duration subgroup than those without of less than 10 years. These findings suggest that diastolic dysfunction in type 2 diabetes is prevalent in those older and considerably influenced by aging.
