Abstract
Small dense low-density lipoprotein (sd-LDL) and postprandial lipemia have been highlighted as risk factors for cardiovascular disease. Such dyslipidemia is widely found in those with type 2 diabetics, but the interaction is poorly understood. We studied the effect of postprandial changes in apolipoprotein (apo) B48, a sensitive postprandial lipemia marker, on sd-LDL increase in 17 healthy controls and 27 subjects with type 2 diabetes. Blood samples were taken at 0, 1, 2, 4, and 6 h after Test meal A ingestion (460 Kcal, 18 g fat) . ApoB48 and triglyceride (TG) were measured and postprandial response calculated as the incremental area under the curve (iAUC) . ApoB48, ApoB48 iAUC, TG, and sd-LDL cholesterol (sd-LDL-C) were higher and lipoproteinlipase lower in those with diabetes than in controls. ApoB48 iAUC, TG, and TG iAUC correlated positively with sd-LDL-C in the overall study population. Multiple regression analysis identified apoB48 iAUC and TG as independent variables of sd-LDL-C, suggesting that postprandial lipemia increases sd-LDL independent of hypertriglycemia.
