Two Cases of Paralytic Ileus Associated with the Administration of Liraglutide

Abstract

Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that has been approved for the treatment of type 2 diabetes. The major side effects of Liraglutide are appetite loss and nausea. There are no reports of ileus among the patients using Liraglutide. This report presents two cases of transient paralytic ileus caused by the administration of Liraglutide. Neither patient had a history of abdominal surgery. Paralytic ileus occurred suddenly accompanied by vomiting in both cases. In addition, an influenza virus infection occurred at the same time as ileus in case 2. Both cases recovered spontaneously after the cessation of Liraglutide. The common clinical features were constipation, the long-term duration of type 2 diabetes, diabetic polyneuropathy and autonomic neuropathy. These cases suggest that physicians and patients should be aware of this serious side effect.