Abstract
A 29-year-old male who was found to have a high HbA1c level at a health checkup visited our hospital for a further examination. His blood glucose level was 92 mg/dl and his HbA1c level was 7.2 %. The pattern of 75 gOGTT was normal, and the levels of glycoalbumin and 1,5-AG were within the normal range. In the analysis of HbA1c using the HPLC method, HbF exhibited a mild increase (1.9 %) and HPLC displayed a high valley between the s-A1c and A0 peaks, suggesting the existence of variant hemoglobin. An analysis with high-quality HPLC revealed a peak in variant hemoglobin near the A0 peak, and the patient was diagnosed with variant hemoglobin. In conclusion, performing a careful analysis of HPLC data in HbA1c measurements helps to detect variant hemoglobin in cases involving suspicion of the HbA1c data.
